A. Nestor-Bergmann

Adhesion dynamics regulate cell intercalation behaviour in an active tissue

This paper develops a mechanical model to study cell intercalation in epithelial tissues, showing that junctional dynamics and adhesion friction regulate neighbour exchanges and tissue deformation.

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

This study shows that kRasV12 oncogene-expressing clusters induce anisotropic strain in host tissue, increasing cell division and altering division orientation, which can be reversed by reducing actomyosin contractility.

Decoupling the roles of cell shape and mechanical stress in orienting and cueing epithelial mitosis

This study decouples the roles of cell shape and mechanical stress in epithelial mitosis orientation and rate using Xenopus laevis tissue.

A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress.

This study identifies a mechanosensitive RhoA pathway mediated by G12 and Myosin VI that protects epithelia from acute tensile stress by increasing junctional actomyosin.