Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response
Y. Yan, J. Xiao, F. Huang, B. Yu, R. Cheng, H. Wu, X. Lu, X. Wang, G. K. Oyejobi, C. V. Robinson, H. Wu, D. Wu, L. Wang, B. Zhu
This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.
bioRxiv · May 25, 2022Microbiology