BiophysicsbioRxiv
Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers
M. de Boer, G. Gouridis, R. Vietrov…·T. Cordes
This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.
DOI 10.7554/elife.44652