M. de Boer

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder

This study finds increased sleep spindle activity in PTSD patients, correlating with intrusive memory symptoms, and introduces a new spindle detection method.

Stability of ligand-induced protein conformation influences affinity in maltose-binding protein

The paper shows that altering the stability of ligand-bound conformations can change ligand affinity in maltose-binding protein, beyond modifying binding site residues.

Triggering closure of a sialic acid TRAP transporter substrate binding protein through binding of natural or artificial substrates

This study investigates the conformational changes in the sialic acid TRAP transporter SBP VcSiaP upon substrate binding, showing that substrate induces closure and provides structural insights for inhibitor development.

Evolution of structural dynamics in bilobed proteins

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

Single-molecule studies of conformational states and dynamics in the ABC importer OpuA

This study uses smFRET to analyze conformational dynamics of OpuA, an ABC importer, revealing ligand-binding mechanisms and ATP/glycine betaine dependencies.

The relation between intrinsic protein conformational changes and ligand binding

The paper uses statistical mechanics to show that ligand-free and ligand-bound proteins can form the same conformations, and that changes in ligand-free conformational equilibrium affect ligand affinity.

The Spectral Fingerprint of Sleep Problems in Post-Traumatic Stress Disorder

This study identifies distinct EEG spectral changes in PTSD patients during NREM and REM sleep, correlating with insomnia and nightmares, and proposes a spectral index as a potential biomarker.

Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers

This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.