Author

S. L. Begg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. A. McDevitt· 2 shared B. M. Collins· 1 shared B. P. Howden· 1 shared B. Poolman· 1 shared B. Winnen· 1 shared F. Husada· 1 shared G. Bierbaum· 1 shared G. F. King· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

C. A. McDevitt

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2 papers

Recent·Most cited

Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers

M. de Boer, G. Gouridis, R. Vietrov, S. L. Begg, G. K. Schuurman-Wolters, F. Husada, N. Eleftheriadis, B. Poolman, C. A. McDevitt, T. Cordes

This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.

bioRxiv · Jan 31, 2019Biophysics

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

I. R. Monk, N. Shaikh, S. L. Begg, M. Gajdiss, J. Y. H. Lee, S. J. Pidot, T. Seemann, M. Kuiper, B. Winnen, R. Hvorup, B. M. Collins, G. Bierbaum, B. P. Howden, C. A. McDevitt, G. F. King, T. P. Stinear

The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.

bioRxiv · Aug 31, 2018Microbiology