G. Gouridis

ABCH2 transporter in the first line of defense protects malaria vectors from pyrethroids

This study identifies ABCH2 as a key transporter that protects malaria vectors from pyrethroid insecticides by directly pumping deltamethrin out of the organism.

Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism

The paper reveals how SecA's intrinsic dynamics and preprotein interactions enable translocation via a catch and release mechanism.

A nexus of intrinsic dynamics underlies translocase priming

This study identifies a dynamic nexus in SecA that primes the Sec translocase for preprotein binding through conserved structural motions and interactions.

Structural and biophysical characterization of the tandem substrate-binding domains of the ABC importer GlnPQ

This paper characterizes the structural and biophysical properties of the tandem substrate-binding domains of the ABC importer GlnPQ using crystal structures, calorimetry, and smFRET.

Evolution of structural dynamics in bilobed proteins

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

Single-molecule studies of conformational states and dynamics in the ABC importer OpuA

This study uses smFRET to analyze conformational dynamics of OpuA, an ABC importer, revealing ligand-binding mechanisms and ATP/glycine betaine dependencies.

Single-molecule observation of ligand binding and conformational changes in FeuA

This study uses single-molecule techniques to observe ligand binding and conformational changes in FeuA, revealing an induced-fit mechanism and ligand-accelerated conformational shifts.

Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers

This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.