Author

G. Kanellos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

C. Nixon· 2 shared D. Strathdee· 2 shared M. Bushell· 2 shared M. Moore· 2 shared O. J. Sansom· 2 shared A. D. Campbell· 1 shared A. Wilczynska· 1 shared B. Cadden· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

C. Nixon

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2 papers

Recent·Most cited

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

M. Moore, L. Pardo, L. Mitchell, T. Schmidt, J. Waldron, S. May, M. Mueller, R. Smith, D. Strathdee, S. Bryson, K. Hodge, S. Lilla, A. Wilczynska, L. McGarry, S. Gillen, , J. C. Norman

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

bioRxiv · Aug 16, 2023 · PreprintCancer Biology