Author

L. Pardo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Nixon· 2 shared J. C. Norman· 2 shared L. Mitchell· 2 shared M. Moore· 2 shared S. Zanivan· 2 shared A. Campos· 1 shared A. J. Graham· 1 shared A. Liu· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

C. Nixon

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Author profile →

4 papers

Recent·Most cited

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

M. Gounis, A. Campos, E. Shokry, L. Mitchell, E. Dornier, N. Rooney, S. Dhayade, L. Pardo, M. Moore, D. Novo, J. Mowat, C. Jamieson, E. Kay, S. Zanivan, C. Nixon, , C. Clarke

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

bioRxiv · May 12, 2024Cancer Biology

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

A. J. Graham, M. W. L. Khoo, V. Srivastava, S. Viragova, H. Kim, K. Parekh, K. M. Hennick, M. Bird, N. Goldhammer, J. Z. Yu, G. Hu, N. T. Brinkley, L. Pardo, J. S. Amaya, C. D. Morley, , Z. J. Gartner

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

bioRxiv · Feb 1, 2024Bioengineering

Structural basis for constitutive activation and CXCL1 recognition of human herpesvirus 8-encoded G protein-coupled receptor KSHV-GPCR

A. Liu, Y. Liu, C. Llinas del Torrent Masachs, W. Zhang, L. Pardo, R. D. Ye

This study determines the cryo-EM structures of KSHV-GPCR in complex with Gi and CXCL1, revealing structural mechanisms of constitutive activation and ligand binding.

bioRxiv · Dec 27, 2023 · PreprintImmunology

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

M. Moore, L. Pardo, L. Mitchell, T. Schmidt, J. Waldron, S. May, M. Mueller, R. Smith, D. Strathdee, S. Bryson, K. Hodge, S. Lilla, A. Wilczynska, L. McGarry, S. Gillen, , J. C. Norman

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

bioRxiv · Aug 16, 2023 · PreprintCancer Biology