J. C. Norman

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

This study identifies how GBM extracellular vesicles containing podocalyxin promote astrocyte hyaluronic acid deposition, enhancing GBM invasiveness.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.

This study shows RAL GTPases activate EGFR/MAPK signaling in intestinal stem cells, promoting proliferation and tumorigenesis, but are independent of oncogenic RAS.

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts

This paper demonstrates the use of iRFP expression in patient-derived glioblastoma cells for non-invasive, quantitative monitoring of tumor growth in vivo.