G. Kinsler

A shift from pleiotropic to modular adaptation revealed by a high-resolution two-step adaptive walk

This study shows that early adaptive mutations in yeast are pleiotropic, while later mutations are modular, focusing on respiration over fermentation.

Improving the accuracy of bulk fitness assays by correcting barcode processing biases

The paper develops a computational method to correct barcode processing biases in bulk fitness assays, improving fitness estimates in yeast variant libraries.

Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

The paper identifies distinct fitness tradeoff groups among fluconazole-resistant yeast mutants, suggesting different resistance mechanisms and implications for multidrug therapy design.

Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch

This study identifies environmental variability as a major source of noise in fitness measurements and proposes best practices for improving precision.