G. M. Arantes

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

The paper presents cryo-EM structures of mitochondrial complex I with and without ubiquinone-10, revealing conformational changes associated with Q-site occupancy.

Combining free energy simulations and NMR chemical-shift perturbation to identify transient cation-π contacts in proteins

The paper identifies transient cation-π contacts in proteins using free energy simulations and NMR chemical shift perturbations, finding two significant interactions in Cdc25B.

Balanced internal hydration discriminates substrate binding to respiratory complex I

The paper investigates how hydration within the protein chamber of respiratory complex I affects the binding of ubiquinone with different tail lengths, revealing a hydration mechanism that influences substrate selectivity and reactivity.

Effects of lipid composition on membrane distribution and permeability of natural quinones

This study uses molecular dynamics simulations to show that membrane unsaturation increases quinone permeability and diffusion by creating a more porous and less ordered bilayer.