Author

H. R. Bridges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Hirst· 3 shared I. Chung· 2 shared A. E. Maclean· 1 shared B. S. Ivanov· 1 shared C. S. Pereira· 1 shared G. M. Arantes· 1 shared J. J. Wright· 1 shared J. N. Blaza· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

J. Hirst

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Author profile →

3 papers

Recent·Most cited

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

H. R. Bridges, J. N. Blaza, Z. Yin, I. Chung, M. N. Pollak, J. Hirst

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

bioRxiv · Aug 9, 2022Biochemistry

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

I. Chung, J. J. Wright, H. R. Bridges, B. S. Ivanov, O. Biner, C. S. Pereira, G. M. Arantes, J. Hirst

The paper presents cryo-EM structures of mitochondrial complex I with and without ubiquinone-10, revealing conformational changes associated with Q-site occupancy.

bioRxiv · Feb 11, 2022Biochemistry

Complexome profile of Toxoplasma gondii mitochondria identifies a divergent cytochrome bc1 complex

A. E. Maclean, H. R. Bridges, M. F. Silva, S. Ding, J. Hirst, L. Sheiner

This study identifies new subunits of Toxoplasma gondii's mitochondrial complex III using complexome profiling, revealing their essential role in parasite survival and drug target potential.

PLOS Pathogens · Mar 2, 2021Peer-reviewedCell Biology