Author

I. Chung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Organism:human· 3 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

J. Hirst· 4 shared H. R. Bridges· 2 shared A. Sanchez-Martinez· 1 shared A. Whitworth· 1 shared A.-N. A. Agip· 1 shared B. S. Ivanov· 1 shared C. S. Pereira· 1 shared C. Soleilhavoup· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

J. Hirst

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

R. E. Hardy, I. Chung, Y. Yu, S. H. Y. Loh, N. Morone, C. Soleilhavoup, M. Travaglio, R. Serreli, L. Panman, K. Cain, J. Hirst, L. M. Martins, M. MacFarlane, K. R. Pryde

This study shows that antipsychotics aripiprazole, brexpiprazole, and cariprazine inhibit mitochondrial respiratory complex I, causing toxicity and movement disorders.

bioRxiv · Apr 2, 2023Pharmacology & Toxicology

Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

A.-N. A. Agip, I. Chung, A. Sanchez-Martinez, A. Whitworth, J. Hirst

The paper determines the Cryo-EM structure of Drosophila melanogaster mitochondrial respiratory complex I, revealing structural homology to mammalian complex I and identifying a novel subunit homologue.

bioRxiv · Nov 1, 2022Biochemistry

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

H. R. Bridges, J. N. Blaza, Z. Yin, I. Chung, M. N. Pollak, J. Hirst

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

bioRxiv · Aug 9, 2022Biochemistry

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

I. Chung, J. J. Wright, H. R. Bridges, B. S. Ivanov, O. Biner, C. S. Pereira, G. M. Arantes, J. Hirst

The paper presents cryo-EM structures of mitochondrial complex I with and without ubiquinone-10, revealing conformational changes associated with Q-site occupancy.

bioRxiv · Feb 11, 2022Biochemistry

TelNet - a database for human and yeast genes involved in telomere maintenance

D. M. Braun, I. Chung, N. Kepper, K. I. Deeg, K. Rippe

TelNet is a database that compiles over 2,000 human and 1,100 yeast genes involved in telomere maintenance, providing annotations and search tools for TM-related research.

bioRxiv · Nov 30, 2017Cancer Biology