Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape
C. Fung, L. M. Fraser, G. M. Barron, M. B. Gologorsky, S. N. Atkinson, E. R. Gerrick, M. Hayward, J. Ziegelbauer, J. A. Li, K. F. Nico, M. D. W. Tyner, L. B. DeSchepper, A. Pan, N. H. Salzman, M. R. Howitt
This study shows that succinate from commensal protists activates tuft cells, leading to changes in antimicrobial peptides and microbiota composition in the small intestine.
bioRxiv · Oct 24, 2022Microbiology