Author

M. R. Howitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:ecology & biodiversity· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

E. R. Gerrick· 3 shared C. Fung· 2 shared C. M. Mechler· 2 shared J. A. Li· 2 shared L. B. DeSchepper· 2 shared M. B. Gologorsky· 2 shared A. Barilli· 1 shared A. M. Spormann· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

E. R. Gerrick

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Commensal protists in reptiles display flexible host range and adaptation to ectothermic hosts

E. R. Gerrick, L. B. DeSchepper, C. M. Mechler, L.-M. Joubert, F. Dunker, T. J. Colston, M. R. Howitt

The paper investigates parabasalid protists in reptiles, finding they have a flexible host range and adapt to temperature changes, but cold temperatures negatively affect their transcriptomes.

bioRxiv · May 25, 2023Microbiology

Tuft cell-derived acetylcholine regulates epithelial fluid secretion

T. E. Billipp, C. Fung, L. M. Webeck, D. B. Sargent, M. B. Gologorsky, M. M. McDaniel, D. N. Kasal, J. W. McGinty, K. A. Barrow, L. M. Rich, A. Barilli, M. Sabat, J. S. Debley, R. Myers, M. R. Howitt, J. von Moltke

This study shows that tuft cell-derived acetylcholine in the intestine triggers immediate fluid secretion, distinct from its role in immune responses, and is involved in Type 2 inflammation and helminth clearance.

bioRxiv · Mar 17, 2023 · PreprintImmunology

Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape

C. Fung, L. M. Fraser, G. M. Barron, M. B. Gologorsky, S. N. Atkinson, E. R. Gerrick, M. Hayward, J. Ziegelbauer, J. A. Li, K. F. Nico, M. D. W. Tyner, L. B. DeSchepper, A. Pan, N. H. Salzman, M. R. Howitt

This study shows that succinate from commensal protists activates tuft cells, leading to changes in antimicrobial peptides and microbiota composition in the small intestine.

bioRxiv · Oct 24, 2022Microbiology

Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

E. R. Gerrick, S. Zlitni, P. T. West, M. M. Carter, C. M. Mechler, M. R. Olm, E. B. Caffrey, J. A. Li, S. K. Higginbottom, C. J. Severyn, F. Kracke, A. M. Spormann, J. L. Sonnenburg, A. S. Bhatt, M. R. Howitt

The paper identifies metabolic diversity in commensal protists and shows how it influences intestinal immunity and trans-kingdom competition with bacteria.

bioRxiv · Aug 26, 2022Microbiology