Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors
D. Matasic, J.-Y. Yoon, J. M. McLendon, H. Mehdi, M. S. Schmidt, A. M. Greiner, P. Quinones, G. M. Morgan, R. L. Boudreau, K. Irani, C. Brenner, B. London
This study investigates how NAD+ precursors NR and NAM affect NaV1.5 currents and cardiac electrophysiology, finding NR increases peak INa and reduces INa,L while NAM has mixed effects.
bioRxiv · Feb 20, 2020Physiology