Author

M. S. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Brenner· 4 shared A. J. Covarrubias· 1 shared A. Kale· 1 shared A. M. Greiner· 1 shared A. Oliveira Pisco· 1 shared A. R. Fehr· 1 shared B. Gunson· 1 shared B. London· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersPathology

C. Brenner

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Author profile →

5 papers

Recent·Most cited

The NAD Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease

R. Parker, M. S. Schmidt, O. Cain, B. Gunson, C. Brenner

This study quantifies the NAD+ metabolome in human liver samples from patients with alcohol-related liver disease and finds reduced NAD+ and precursor levels associated with disease activity.

Hepatology Communications · May 31, 2020Peer-reviewedPathology

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology

Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors

D. Matasic, J.-Y. Yoon, J. M. McLendon, H. Mehdi, M. S. Schmidt, A. M. Greiner, P. Quinones, G. M. Morgan, R. L. Boudreau, K. Irani, C. Brenner, B. London

This study investigates how NAD+ precursors NR and NAM affect NaV1.5 currents and cardiac electrophysiology, finding NR increases peak INa and reduces INa,L while NAM has mixed effects.

bioRxiv · Feb 20, 2020Physiology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology

Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review

L. N. Toksvang, K. Schmiegelow, M. S. Schmidt, S. Arup, R. H. Larsen, T. L. Frandsen, C. U. Rank

This review assesses hepatotoxicity risks of 6-thioguanine treatment in ALL and IBD patients, finding that lower doses (≤12 mg/m2/day) are associated with minimal hepatotoxicity.

bioRxiv · Jan 31, 2019Pharmacology & Toxicology