Author

K. Irani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. London· 3 shared J.-Y. Yoon· 3 shared C. Brenner· 2 shared H. Mehdi· 2 shared A. Greiner· 1 shared A. M. Greiner· 1 shared A. Vikram· 1 shared B. Chen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersPhysiology

B. London

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Author profile →

3 papers

Recent·Most cited

SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability

J.-Y. Yoon, A. Greiner, J. S. Jacobs, Y.-R. Kim, T. P. Rasmussen, W. Kutschke, D. S. Matasic, A. Vikram, R. R. Gaddam, H. Mehdi, K. Irani, B. London

This study investigates how SUMOylation of NaV1.5 affects cardiac sodium current and electrophysiology, finding it increases peak INa without altering INa,L and may influence arrhythmic risk.

bioRxiv · Dec 26, 2022Physiology

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

J.-Y. Yoon, N. Daneshgar, Y. Chu, B. Chen, M. Hefti, K. Irani, L.-S. Song, C. Brenner, E. D. Abel, B. London, D.-F. Dai

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

bioRxiv · Jan 4, 2022Pathology

Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors

D. Matasic, J.-Y. Yoon, J. M. McLendon, H. Mehdi, M. S. Schmidt, A. M. Greiner, P. Quinones, G. M. Morgan, R. L. Boudreau, K. Irani, C. Brenner, B. London

This study investigates how NAD+ precursors NR and NAM affect NaV1.5 currents and cardiac electrophysiology, finding NR increases peak INa and reduces INa,L while NAM has mixed effects.

bioRxiv · Feb 20, 2020Physiology