Redox sensitive E2 Rad6 controls cellular response to oxidative stress via K63 ubiquitination of ribosomes.
V. Simoes, L. Harley, B. K. Cizubu, Y. Zhou, J. Pajak, N. A. Snyder, J. Bouvette, M. J. Borgnia, G. Arya, A. Bartesaghi, G. M. Silva
The paper identifies Rad6 as a redox-sensitive E2 enzyme that modifies ribosomes with K63 ubiquitin during oxidative stress, linking it to translation control and stress response.
bioRxiv · Apr 22, 2021Cell Biology