PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism
L. Simula, V. Cancila, Y. Antonucci, A. Colamatteo, C. Procaccini, G. Matarese, C. Tripodo, S. Campello
This study shows PD-1 signalling reduces Drp1 activity in tumor-infiltrating T cells, leading to mitochondrial fusion and impaired T cell function.
bioRxiv · Jul 14, 2020Immunology