C. Tripodo

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

ZEB1 shapes AML immunological niches suppressing CD8 T-cell activity while fostering Th17 cell expansion.

This study shows ZEB1 in AML suppresses CD8 T-cells and promotes Th17 cells, contributing to immune suppression and tumor progression.

A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

This study shows that aging-related telomere shortening and DNA damage response increase ACE2 expression, making elderly individuals more susceptible to SARS-CoV-2 infection.

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

This study demonstrates that neutrophil extracellular traps (NETs) loaded with mutant NPMc+ can be used as a vaccine to treat NPMc-driven myeloproliferation by inducing CD8+ T cell responses and reducing leukemic expansion.

SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches

This study shows that cisplatin promotes metastasis by creating pro-metastatic niches, which can be blocked by CXCR4 inhibition.

CD40 provides immune privilege to the bone marrow hematopoietic niche

This study shows that CD40 on bone marrow mesenchymal stem cells (BM-MSCs) promotes immune tolerance and prevents graft-versus-host disease by regulating Treg function and B-cell development.

SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis

This study shows that SPARC deficiency leads to increased PMN clearance failure, promoting autoimmunity in lupus and arthritis models.

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism

This study shows PD-1 signalling reduces Drp1 activity in tumor-infiltrating T cells, leading to mitochondrial fusion and impaired T cell function.

Intra-tumor heterogeneity of Diffuse Large B-cell Lymphoma involves the induction of diversified stroma-tumor interfaces

This study investigates how stromal adaptations in the tumor microenvironment contribute to intra-tumor heterogeneity in DLBCL, showing their impact on transcriptional programs and MYC expression.

Compromised nuclear envelope integrity drives tumor cell invasion

The paper shows that mechanical nuclear envelope ruptures in cancer cells cause DNA damage and promote invasion through ATM activation and TREX1 depletion.

ATR expands embryonic stem cell fate potential in response to replication stress

This study identifies an ATR-CHK1 pathway in ESCs that enhances fate potential by inducing 2C-like gene expression in response to replication stress.

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

This study identifies the RAB5A-driven endo-ERK1/2 pathway as a mechanism for unjamming in epithelial tissues and carcinoma, enabling collective motility and invasion.