Author

G. Modica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Sauvageau· 3 shared S. Lefrancois· 3 shared S. Yasa· 2 shared A. Kaleem· 1 shared G. Hermey· 1 shared J. Maes· 1 shared L. Tejeda-Valencia· 1 shared O. Skorobogata· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

E. Sauvageau

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3 papers

Recent·Most cited

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment

G. Modica, L. Tejeda-Valencia, E. Sauvageau, J. Maes, O. Skorobogata, S. Lefrancois

This study shows that phosphorylation of Rab7A at serine 72 modulates its palmitoylation and retromer recruitment, with NEK7 as the kinase responsible for this phosphorylation.

bioRxiv · Apr 1, 2024Cell Biology

CLN5 and CLN3 function as a complex to regulate endolysosome function

S. Yasa, E. Sauvageau, G. Modica, S. Lefrancois

This paper shows that CLN5 and CLN3 form a complex that regulates endolysosome function by modulating retromer and Rab7A interactions, affecting endocytic protein degradation and autophagy.

bioRxiv · Dec 24, 2020Cell Biology

CLN3 regulates endosomal function by modulating Rab7A activity

S. Yasa, G. Modica, E. Sauvageau, A. Kaleem, G. Hermey, S. Lefrancois

This study identifies CLN3's role in regulating Rab7A activity to control endosomal trafficking and autophagy, explaining JNCL pathogenesis.

bioRxiv · May 10, 2019 · PreprintCell Biology