Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response
K. A. Sun, Y. Li, A. Y. Meliton, P. S. Woods, L. M. Kimmig, R. B. Hamanaka, G. Mutlu
This study shows endogenous itaconate is not required for PM-induced NRF2 expression or inflammation, but exogenous itaconate can suppress inflammation and activate NRF2.
bioRxiv · Jan 19, 2020Cell Biology