HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophagesto promote survival during acute lung injury
P. S. Woods, L. M. Kimmig, K. A. Sun, A. Y. Meliton, O. R. Shamaa, Y. Tian, R. Cetin-Atalay, W. W. Sharp, R. B. Hamanaka, G. M. Mutlu
This study shows hypoxia stabilizes HIF-1α in alveolar macrophages, promoting glycolytic reprogramming that enhances survival during acute lung injury.
bioRxiv · Feb 28, 2022Cell Biology