Constrained mutational sampling of amino acids in HIV-1 protease evolution
J. I. Boucher, T. W. Whitfield, A. Dauphin, G. Nauchum, K. B. Zeldovich, R. Swanstrom, C. A. Schiffer, J. Luban, D. N. A. Bolon
The paper investigates HIV-1 protease evolution by comparing experimental fitness landscapes with sequenced isolate data, showing mutational sampling influences multiple mutations.
bioRxiv · Jan 28, 2019Evolutionary Biology