D. N. A. Bolon

The paper systematically identifies new allosteric regulatory sites in Gsp1/Ran by mutational scanning, revealing that many deleterious mutations affect function outside the active site through allosteric coupling.

The paper quantifies how adaptation costs vary across environments by analyzing mutations in the middle domain of yeast Hsp90, finding low adaptation cost and identifying regions enriched in beneficial or deleterious mutations.

This study maps the fitness effects of Hsp90 variants across multiple environments, showing widespread environmental dependence and selection for robustness.

The paper investigates HIV-1 protease evolution by comparing experimental fitness landscapes with sequenced isolate data, showing mutational sampling influences multiple mutations.

The paper measures the fitness effects of historical amino acid substitutions in Hsp90 across evolutionary timescales, finding pervasive epistasis influencing sequence evolution and entrenchment.