Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling
J. D. Frenster, G. Stephan, N. Ravn-Boess, D. Bready, J. Wilcox, B. Kieslich, C. Wilde, N. Sträter, G. R. Wiggin, I. Liebscher, T. Schöneberg, D. G. Placantonakis
This study shows that cleavage of GPR133 into NTF and CTF fragments at the plasma membrane enhances canonical signaling in GBM and HEK293T cells compared to an uncleavable mutant.
bioRxiv · Dec 8, 2020 · PreprintCell Biology