Author

D. G. Placantonakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. D. Frenster· 5 shared D. Bready· 4 shared G. Stephan· 4 shared I. Liebscher· 3 shared J. Wilcox· 3 shared N. Ravn-Boess· 3 shared B. Kieslich· 2 shared C. Wilde· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCell Biology

J. D. Frenster

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

N. Ravn-Boess, N. Roy, T. Hattori, D. Bready, H. Donaldson, C. Lawson, C. Lapierre, A. Korman, T. Rodrick, E. Liu, J. D. Frenster, G. Stephan, J. Wilcox, A. D. Corrado, J. Cai, , D. G. Placantonakis

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.

Cell Reports · Nov 1, 2023Peer-reviewedCancer Biology

PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM

J. D. Frenster, H. Erdjument-Bromage, W. Liu, G. Stephan, N. Ravn-Boess, D. Bready, J. Wilcox, B. Kieslich, M. Jankovic, C. Wilde, S. Horn, N. Straeter, I. Liebscher, T. Schoneberg, D. Fenyö, , D. G. Placantonakis

This study identifies PTK7 as a positive allosteric modulator of GPR133 signaling in glioblastoma, showing that their interaction enhances receptor activation and is relevant to tumor pathogenesis.

bioRxiv · Jun 15, 2022 · PreprintCell Biology

Activation of the adhesion GPCR GPR133 (ADGRD1) by antibodies targeting the N-terminus

G. Stephan, J. D. Frenster, I. Liebscher, D. G. Placantonakis

This study shows that antibodies targeting the N-terminus of GPR133 promote receptor activation by inducing NTF-CTF dissociation, increasing cAMP levels in GBM cells.

bioRxiv · Sep 13, 2021 · PreprintCell Biology

The H3K36me2 writer-reader dependency in H3K27M-DIPG

J.-R. Yu, G. LeRoy, D. Bready, J. D. Frenster, R. Saldana-Meyer, Y. Jin, N. Descostes, J. M. Stafford, D. G. Placantonakis, D. Reinberg

This study identifies NSD1/2 as key writers and LEDGF/HDGF2 as readers of H3K36me2 in H3K27M-DIPG, showing their role in tumor proliferation and suggesting therapeutic targeting.

bioRxiv · Jan 6, 2021Cancer Biology

Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling

J. D. Frenster, G. Stephan, N. Ravn-Boess, D. Bready, J. Wilcox, B. Kieslich, C. Wilde, N. Sträter, G. R. Wiggin, I. Liebscher, T. Schöneberg, D. G. Placantonakis

This study shows that cleavage of GPR133 into NTF and CTF fragments at the plasma membrane enhances canonical signaling in GBM and HEK293T cells compared to an uncleavable mutant.

bioRxiv · Dec 8, 2020 · PreprintCell Biology