Author

N. Ravn-Boess

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

D. Bready· 4 shared G. Stephan· 4 shared D. G. Placantonakis· 3 shared J. D. Frenster· 3 shared J. Wilcox· 3 shared B. Kieslich· 2 shared C. Wilde· 2 shared D. Fenyo· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCell Biology

D. Bready

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Author profile →

4 papers

Recent·Most cited

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

N. Ravn-Boess, N. Roy, T. Hattori, D. Bready, H. Donaldson, C. Lawson, C. Lapierre, A. Korman, T. Rodrick, E. Liu, J. D. Frenster, G. Stephan, J. Wilcox, A. D. Corrado, J. Cai, , D. G. Placantonakis

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.

Cell Reports · Nov 1, 2023Peer-reviewedCancer Biology

Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1)

G. Stephan, W. Liu, J. Frenster, N. Ravn-Boess, D. Bready, J. Cai, D. Fenyo, T. A. Neubert, D. Placantonakis

This study identifies ESYT1 as an intracellular modulator of GPR133 signaling, showing that Ca2+ levels influence their interaction and affect cAMP levels in glioblastoma cells.

bioRxiv · Feb 9, 2023Cell Biology

PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM

J. D. Frenster, H. Erdjument-Bromage, W. Liu, G. Stephan, N. Ravn-Boess, D. Bready, J. Wilcox, B. Kieslich, M. Jankovic, C. Wilde, S. Horn, N. Straeter, I. Liebscher, T. Schoneberg, D. Fenyö, , D. G. Placantonakis

This study identifies PTK7 as a positive allosteric modulator of GPR133 signaling in glioblastoma, showing that their interaction enhances receptor activation and is relevant to tumor pathogenesis.

bioRxiv · Jun 15, 2022 · PreprintCell Biology

Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling

J. D. Frenster, G. Stephan, N. Ravn-Boess, D. Bready, J. Wilcox, B. Kieslich, C. Wilde, N. Sträter, G. R. Wiggin, I. Liebscher, T. Schöneberg, D. G. Placantonakis

This study shows that cleavage of GPR133 into NTF and CTF fragments at the plasma membrane enhances canonical signaling in GBM and HEK293T cells compared to an uncleavable mutant.

bioRxiv · Dec 8, 2020 · PreprintCell Biology