Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers
M. Mastri, S. Ramakrishnan, S. Shah, E. Karasik, B. M. Gillard, M. M. Moser, B. K. Farmer, G. S. Chatta, A. Woloszynska, K. H. Eng, B. A. Foster, W. J. HUSS
This study compares gene expression profiles of patient-derived models (PDMs) with surgical specimens of bladder cancer, finding PDXs most similar to original tumors while maintaining EMT and molecular subtype markers.
bioRxiv · Feb 10, 2021 · PreprintCancer Biology