W. J. Huss

Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer

This paper establishes syngeneic bladder cancer tumor lines that mimic human molecular and immunological features of muscle-invasive bladder cancer subtypes and test cisplatin response.

Racial differences in androgen metabolism and receptor signaling in prostate cancer

This study identifies racial differences in androgen metabolism and receptor signaling in prostate cancer, showing African American men use an alternative pathway for DHT biosynthesis associated with disease progression.

Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers

This study compares gene expression profiles of patient-derived models (PDMs) with surgical specimens of bladder cancer, finding PDXs most similar to original tumors while maintaining EMT and molecular subtype markers.

Ultra-deep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.