B. M. Gillard

Endogenous CD28 drives CAR T cell responses in multiple myeloma

This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.

Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer

This paper establishes syngeneic bladder cancer tumor lines that mimic human molecular and immunological features of muscle-invasive bladder cancer subtypes and test cisplatin response.

Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers

This study compares gene expression profiles of patient-derived models (PDMs) with surgical specimens of bladder cancer, finding PDXs most similar to original tumors while maintaining EMT and molecular subtype markers.