Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome
I. J. Marie, L. Brambilla, D. Azzouz, Z. Chen, G. V. Baracho, A. Arnett, H. S. Li, W. Liu, L. Cimmino, P. Chattopadhyay, G. Silverman, S. S. Watowich, B. Khor, D. Levy
This study shows that tonic interferon signaling maintains immune homeostasis by regulating gut microbiota, preventing IL-17-driven inflammation and myeloid hyperplasia in STAT1 KO mice.
bioRxiv · Apr 21, 2021Immunology