Author

I. J. Marie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Arnett· 2 shared B. Khor· 2 shared A. F. Shamji· 1 shared D. Azzouz· 1 shared D. E. Levy· 1 shared D. Levy· 1 shared G. Silverman· 1 shared G. V. Baracho· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. Arnett

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Author profile →

2 papers

Recent·Most cited

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

I. J. Marie, L. Brambilla, D. Azzouz, Z. Chen, G. V. Baracho, A. Arnett, H. S. Li, W. Liu, L. Cimmino, P. Chattopadhyay, G. Silverman, S. S. Watowich, B. Khor, D. Levy

This study shows that tonic interferon signaling maintains immune homeostasis by regulating gut microbiota, preventing IL-17-driven inflammation and myeloid hyperplasia in STAT1 KO mice.

bioRxiv · Apr 21, 2021Immunology

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

A. Arnett, K. G. Moo, K. J. Flynn, T. B. Sundberg, L. Johannessen, A. F. Shamji, N. S. Gray, T. Decker, V. H. Gersuk, D. E. Levy, I. J. Marie, Z. S. Rahman, Y. Zheng, P. S. Linsley, R. J. Xavier, B. Khor

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

bioRxiv · Mar 4, 2021 · PreprintImmunology