Hydrogen Peroxide Production by Epidermal Dual Oxidase 1 Regulates Nociceptive Sensory Signals
A. Pato, K. Bölcskei, A. Donko, D. Kaszas, M. Boros, L. Bodrogi, G. Varady, V. F. Pape, B. Roux, B. Enyedi, Z. Helyes, F. M. Watt, G. Sirokmany, M. Geiszt
The paper shows that DUOX1 in keratinocytes produces hydrogen peroxide, modulating nociceptive signals via TRPA1 and potassium channels in sensory neurons.
bioRxiv · Sep 11, 2022Physiology