F. M. Watt

Neutral evolution of snoRNA Host Gene long non-coding RNA affects cell fate control

The paper shows that neutrally evolving lncRNAs from SNHGs influence cell fate and are involved in epidermal homeostasis through microRNA binding.

Multi-scale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma

The paper creates a multi-scale spatial atlas of healthy human skin and basal cell carcinoma using various omics and imaging techniques, revealing cell population localization and origins.

Hydrogen Peroxide Production by Epidermal Dual Oxidase 1 Regulates Nociceptive Sensory Signals

The paper shows that DUOX1 in keratinocytes produces hydrogen peroxide, modulating nociceptive signals via TRPA1 and potassium channels in sensory neurons.

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage

This study investigates the role of fibroblast lineages and immune cells in dermal repair after UV radiation damage, finding that T cells support fibroblast survival and that COX-2 inhibition prevents fibroblast depletion.

ERK basal and pulsatile activity are differentially regulated in mammalian epidermis to control proliferation and exit from the stem cell compartment

The paper shows that ERK activity in mammalian epidermis is regulated by pulsatile and basal dynamics, with DUSP10 and DUSP6 controlling different aspects of differentiation.

IMMUNOMODULATORY ROLE OF KERATIN 76 IN ORAL AND GASTRIC CANCER

This study shows that Krt76 loss in epithelial cells promotes carcinogenesis by enhancing Treg function and pro-inflammatory cytokines in mouse models and human OSCC.