Author

G. T. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. R. Donald· 3 shared A. A. Ojewole· 2 shared D. L. Wright· 2 shared M. S. Frenkel· 2 shared S. M. Reeve· 2 shared S. Wang· 2 shared A. Estrada· 1 shared A. J. Weimer· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

B. R. Donald

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Author profile →

3 papers

Recent·Most cited

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

S. Wang, S. M. Reeve, A. A. Ojewole, M. S. Frenkel, G. T. Holt, P. Gainza, S. Keshipeddy, V. G. Fowler, D. L. Wright, B. R. Donald

The paper investigates how a mutation in Staphylococcus aureus dihydrofolate reductase affects antifolate resistance and NADPH isomerism through chiral evasion mechanisms.

bioRxiv · Jul 28, 2020Biochemistry

Computational Analysis of Energy Landscapes Reveals Dynamic Features that Contribute to Binding of Inhibitors to CFTR-Associated Ligand

G. T. Holt, J. D. Jou, N. P. Gill, A. U. Lowegard, J. W. Martin, D. R. Madden, B. R. Donald

The paper analyzes energy landscapes of CALP-inhibitor complexes to identify structural and dynamic features contributing to binding efficiency of kCAL01.

The Journal of Physical Chemistry B · Nov 7, 2019Peer-reviewedBiochemistry

Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

S. M. Reeve, D. Si, J. Krucinska, Y. Yan, K. Viswanathan, S. Wang, G. T. Holt, M. S. Frenkel, A. A. Ojewole, A. Estrada, S. S. Agabiti, J. B. Alverson, N. D. Gibson, A. J. Weimer, B. R. Donald, D. L. Wright

The paper develops novel inhibitors targeting DHFR enzymes in MRSA to overcome trimethoprim resistance, showing low nanomolar activity and human selectivity.

bioRxiv · May 24, 2019Biochemistry