Author

D. R. Madden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:protein folding & dynamics· 4 Organism:bacteria (other)· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. D. Bahl· 2 shared K. L. Hvorecny· 2 shared N. M. Taher· 2 shared N. P. Gill· 2 shared A. B. Hickman· 1 shared A. U. Lowegard· 1 shared B. R. Donald· 1 shared C. M. Burke· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. D. Bahl

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa

S. He, N. M. Taher, K. L. Hvorecny, M. J. Ragusa, C. D. Bahl, A. B. Hickman, F. Dyda, D. R. Madden

This study identifies the molecular mechanisms by which CifR, an epoxide-sensing transcriptional repressor, regulates the virulence gene cif in Pseudomonas aeruginosa.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets

E. F. Tahti, J. M. Blount, S. N. Jackson, M. Gao, N. P. Gill, S. N. Smith, N. J. Pederson, S. N. Rumph, S. A. Struyvenberg, I. G. P. Mackley, D. R. Madden, J. Amacher

bioRxiv · Dec 31, 2022Biochemistry

Stereochemistry of transient protein-protein interactions in a signaling hub: exploring G3BP1-mediated regulation of CFTR deubiquitination

C. T. Sheehan, D. R. Madden

This study investigates how small changes in binding affinity affect the composition of protein interaction hubs, using G3BP1 mutations to alter interactions with USP10 and Caprin1.

bioRxiv · Mar 2, 2022Biochemistry

Biochemical and Structural Characterization of Two Cif-Like Epoxide Hydrolases from Burkholderia cenocepacia

N. M. Taher, K. L. Hvorecny, C. M. Burke, M. S. A. Gilman, G. E. Heussler, J. Adolf-Bryfogle, C. D. Bahl, G. A. O'Toole, D. R. Madden

This study characterizes two Cif-like epoxide hydrolases from Burkholderia cenocepacia, revealing their biochemical properties and structural differences.

bioRxiv · Jan 20, 2021Biochemistry

Computational Analysis of Energy Landscapes Reveals Dynamic Features that Contribute to Binding of Inhibitors to CFTR-Associated Ligand

G. T. Holt, J. D. Jou, N. P. Gill, A. U. Lowegard, J. W. Martin, D. R. Madden, B. R. Donald

The paper analyzes energy landscapes of CALP-inhibitor complexes to identify structural and dynamic features contributing to binding efficiency of kCAL01.

The Journal of Physical Chemistry B · Nov 7, 2019Peer-reviewedBiochemistry