PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor
R. Ambler, G. L. Edmunds, G. Toti, D. J. Morgan, C. Wuelfing
The paper investigates how PD-1 signaling affects CD8+ T cell interactions with tumor cells, finding that PD-1 suppresses cell couple maintenance and tumor cell killing by impairing actin dynamics.
bioRxiv · Oct 16, 2018Immunology