Author

R. Ambler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Wuelfing· 2 shared D. J. Morgan· 2 shared G. L. Edmunds· 2 shared C. Moore· 1 shared C. W. L. Wong· 1 shared E. Milodowski· 1 shared E. Mugarza· 1 shared F. van Maldegem· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

C. Wuelfing

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, R. Ambler, P. Anastasiou, P. R. Clavijo, K. Valand, M. Cole, M. Molina-Arcas, J. Downward

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

bioRxiv · Oct 18, 2021Cancer Biology

The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization

G. L. Edmunds, C. W. L. Wong, R. Ambler, E. Milodowski, H. Alamir, S. J. Cross, G. Galea, C. Wuelfing, D. J. Morgan

This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.

bioRxiv · May 20, 2021Immunology

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

R. Ambler, G. L. Edmunds, G. Toti, D. J. Morgan, C. Wuelfing

The paper investigates how PD-1 signaling affects CD8+ T cell interactions with tumor cells, finding that PD-1 suppresses cell couple maintenance and tumor cell killing by impairing actin dynamics.

bioRxiv · Oct 16, 2018Immunology