Author

D. J. Morgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Wuelfing· 3 shared G. L. Edmunds· 3 shared H. Alamir· 2 shared R. Ambler· 2 shared A. Alsubaiti· 1 shared A. M. Gallimore· 1 shared B. Coats· 1 shared C. J. Holland· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

C. Wuelfing

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TIM3 is a context-dependent co-regulator of cytotoxic T cell function

H. Alamir, C. W. C. Wong, A. Alsubaiti, G. L. Edmunds, T. Grant, S. Alsulaimani, J. Boyd, C. J. Holland, D. J. Morgan, A. M. Gallimore, C. Wuelfing

This study shows TIM3 inhibits spheroid-suppressed CTL but not active CTL, and its function depends on the context of T cell activation and ligand expression.

bioRxiv · Aug 3, 2023Immunology

Confocal reflectance microscopy for mapping collagen fiber organization in the vitreous gel of the eye

E. S. Hwang, D. J. Morgan, J. Sun, M. E. Hartnett, K. C. Toussaint, B. Coats

This study uses confocal reflectance microscopy to map collagen fiber organization in porcine vitreous, revealing fiber density variations and poor alignment.

bioRxiv · Nov 9, 2022Biochemistry

The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization

G. L. Edmunds, C. W. L. Wong, R. Ambler, E. Milodowski, H. Alamir, S. J. Cross, G. Galea, C. Wuelfing, D. J. Morgan

This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.

bioRxiv · May 20, 2021Immunology

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

R. Ambler, G. L. Edmunds, G. Toti, D. J. Morgan, C. Wuelfing

The paper investigates how PD-1 signaling affects CD8+ T cell interactions with tumor cells, finding that PD-1 suppresses cell couple maintenance and tumor cell killing by impairing actin dynamics.

bioRxiv · Oct 16, 2018Immunology