Author

C. Wuelfing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. J. Morgan· 3 shared G. L. Edmunds· 3 shared H. Alamir· 2 shared R. Ambler· 2 shared S. J. Cross· 2 shared A. Alsubaiti· 1 shared A. M. Gallimore· 1 shared A. M. Phillips· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

D. J. Morgan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TIM3 is a context-dependent co-regulator of cytotoxic T cell function

H. Alamir, C. W. C. Wong, A. Alsubaiti, G. L. Edmunds, T. Grant, S. Alsulaimani, J. Boyd, C. J. Holland, D. J. Morgan, A. M. Gallimore, C. Wuelfing

This study shows TIM3 inhibits spheroid-suppressed CTL but not active CTL, and its function depends on the context of T cell activation and ligand expression.

bioRxiv · Aug 3, 2023Immunology

Five inhibitory receptors display distinct vesicular distributions in T cells

J. Lu, A. Veler, B. Simonetti, T. Raj, P. H. Chou, S. J. Cross, A. M. Phillips, X. Ruan, L. Huynh, A. W. Dowsey, D. Ye, R. F. Murphy, P. Verkade, P. J. Cullen, C. Wuelfing

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

bioRxiv · Jul 21, 2023Immunology

ADAPs intrinsically disordered region is an actin sponge regulating T cell motility

N. Dadwal, J. Degen, J. Sticht, T. Hilal, T. Wegner, P. Reichardt, R. Lyck, M. Hons, M. Abadier, C. Mix, B. Kuropka, H. Stephanowitz, F. Liu, B. Schraven, C. Wuelfing, , C. Freund

This study identifies ADAP's intrinsically disordered region as an actin sponge that regulates T cell motility by promoting actin polymerization and bundling.

bioRxiv · Dec 14, 2021 · PreprintBiochemistry

The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization

G. L. Edmunds, C. W. L. Wong, R. Ambler, E. Milodowski, H. Alamir, S. J. Cross, G. Galea, C. Wuelfing, D. J. Morgan

This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.

bioRxiv · May 20, 2021Immunology

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

R. Ambler, G. L. Edmunds, G. Toti, D. J. Morgan, C. Wuelfing

The paper investigates how PD-1 signaling affects CD8+ T cell interactions with tumor cells, finding that PD-1 suppresses cell couple maintenance and tumor cell killing by impairing actin dynamics.

bioRxiv · Oct 16, 2018Immunology