Author

G. V. Brierley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

E. Rasijeff· 1 shared H. Su· 1 shared H. Webber· 1 shared K. Siddle· 1 shared O. Perisic· 1 shared P. R. Tomlinson· 1 shared R. K. Semple· 1 shared R. Knox· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

E. Rasijeff

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2 papers

Recent·Most cited

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

P. R. Tomlinson, R. Knox, O. Perisic, H. Su, G. V. Brierley, R. L. Williams, R. K. Semple

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

bioRxiv · Nov 2, 2023Biochemistry

Anti-Insulin receptor antibodies improve hyperglycaemia in a mouse model of human insulin receptoropathy

G. V. Brierley, H. Webber, E. Rasijeff, S. Grocott, K. Siddle, R. Semple

Anti-insulin receptor antibodies improve glucose tolerance and reduce hyperinsulinemia in a mouse model of insulin receptoropathy but also downregulate receptor expression.

bioRxiv · Mar 20, 2020Biochemistry