Author

R. Knox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Mahler-Araujo· 1 shared B. Vanhaesebroeck· 1 shared G. V. Brierley· 1 shared H. Su· 1 shared N. McGranahan· 1 shared O. Perisic· 1 shared P. R. Tomlinson· 1 shared R. K. Semple· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

B. Mahler-Araujo

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2 papers

Recent·Most cited

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

P. R. Tomlinson, R. Knox, O. Perisic, H. Su, G. V. Brierley, R. L. Williams, R. K. Semple

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

bioRxiv · Nov 2, 2023Biochemistry

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

R. Madsen, R. Knox, W. Pearce, S. Lopez, B. Mahler-Araujo, N. McGranahan, B. Vanhaesebroeck, R. Semple

This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.

bioRxiv · Dec 13, 2018Cancer Biology