Author

P. R. Tomlinson

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

G. V. Brierley· 1 shared H. Su· 1 shared O. Perisic· 1 shared R. K. Semple· 1 shared R. Knox· 1 shared R. L. Williams· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

G. V. Brierley

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1 paper

Recent·Most cited

BiochemistrybioRxivNov 2, 2023

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

P. R. Tomlinson, R. Knox, O. Perisic…·R. K. Semple

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

DOI 10.7554/elife.94420

humanproteomics