Transmission-selective muscle pathology induced by active propagation of mutant huntingtin across the human neuromuscular synapse
Dinamarca C. Margarita, Laura Colombo, Brykczynska Urszulax, Amandine Grimm, T. Natalia, Isabelle Fruh, Imtiaz Hossain, Gabriel Daniela, Anne Eckert, M. Müller Matthias, Eline Pecho‐Vrieseling
This study shows that mutant huntingtin spreads across neuromuscular junctions, causing muscle pathology in human cells and mice, suggesting transmission as a therapeutic target for neurodegenerative diseases.
bioRxiv · Jul 28, 2021 · PreprintNeuroscience