Anne Eckert

Abnormal Tau Protein Influences Intercellular Mitochondrial Transfer Between Astrocytic and Neuronal Cells

This study shows abnormal tau protein increases mitochondrial transfer from astrocytes to neurons via contact-dependent mechanisms, affecting mitochondrial function in tauopathies.

Human iPSCs from aged donors retain their mitochondrial aging signature

This study shows that iPSCs from aged donors retain mitochondrial aging features like impaired bioenergetics and increased reactive oxygen species, suggesting they can model mitochondrial aging for drug screening.

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

This study compares aging-related mitochondrial characteristics in iPSC-derived neurons and direct conversion neurons, finding both retain age-associated phenotypes but differ in metabolic responses.

Transmission-selective muscle pathology induced by active propagation of mutant huntingtin across the human neuromuscular synapse

This study shows that mutant huntingtin spreads across neuromuscular junctions, causing muscle pathology in human cells and mice, suggesting transmission as a therapeutic target for neurodegenerative diseases.

Effects of learning and escitalopram administration on serum BDNF levels, a randomised placebo-controlled trial

This study examines how associative learning and escitalopram affect serum BDNF levels in healthy humans, finding significant time effects during learning and a negative correlation between citalopram and sBDNF levels.