Author

Isabelle Fruh

Novartis Institutes for BioMedical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:rat· 1

Frequent Co-Authors

János VörösiD· 2 shared Jens DuruiD· 2 shared Magdalena Krubner· 2 shared Matthias Müller· 2 shared Sophie GirardiniD· 2 shared Stephan J. IhleiD· 2 shared Tobias RuffiD· 2 shared Amandine GrimmiD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

János VörösORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Engineering circuits of human iPSC-derived neurons and rat primary glia

Sophie Girardin, Stephan J. Ihle, Arianna Menghini, Magdalena Krubner, Leonardo Tognola, Jens Duru, Tobias Ruff, Isabelle Fruh, Matthias Müller, János Vörös

This paper develops in vitro neuron-glia circuits using human iPSC-derived neurons and rat glia to test neuroactive compounds.

bioRxiv · Nov 7, 2022 · PreprintNeuroscience

Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings

Sophie Girardin, Blandine Clément, Stephan J. Ihle, Sean M. Weaver, Jana B. Petr, José C. Mateus, Jens Duru, Magdalena Krubner, Csaba Forró, Tobias Ruff, Isabelle Fruh, Matthias Müller, János Vörös

The paper presents a method to create topologically controlled circuits of human iPSC-derived neurons for long-term electrophysiology recordings.

Lab on a Chip · Jan 1, 2022Peer-reviewedNeuroscience

Transmission-selective muscle pathology induced by active propagation of mutant huntingtin across the human neuromuscular synapse

Dinamarca C. Margarita, Laura Colombo, Brykczynska Urszulax, Amandine Grimm, T. Natalia, Isabelle Fruh, Imtiaz Hossain, Gabriel Daniela, Anne Eckert, M. Müller Matthias, Eline Pecho‐Vrieseling

This study shows that mutant huntingtin spreads across neuromuscular junctions, causing muscle pathology in human cells and mice, suggesting transmission as a therapeutic target for neurodegenerative diseases.

bioRxiv · Jul 28, 2021 · PreprintNeuroscience