Granulocyte Colony Stimulating Factor causes cerebellar deficits and anxiety in a mouse model of CSF-1 receptor-related leukoencephalopathy
Fabrizio Biundo, Violeta Chiţu, Jaafar O. Tindi…·E. Richard Stanley
This study shows that reducing Csf3 in Csf1r+/- mice improves anxiety, motor coordination, and social interaction but not cognitive deficits, and reduces microglial activation in the cerebellum.