Mitochondrial Optic Atrophy (OPA)1 expression regulates the injury response to neonatal hypoxia-ischaemia.
Claire J. M. Curel, Adam Jones, Abbe Harper Crawford, Ane Goikolea-Vives, Gwladys Chabrier, Gabriela Gil, Alain Oregioni, Richard Southworth, Thomas R. Eykyn, Helen B. Stolp, Irene Nobeli, Claire Thornton
This study shows that OPA1 expression affects mitochondrial function and DNA content in neonatal hypoxia-ischaemia, with OPA1 loss leading to mitochondrial fragmentation and increased brain injury.
bioRxiv · Jul 10, 2026 · PreprintNeuroscience